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25-ヒドロキシビタミン D(25-OH-(VD3+VD2))抗体および抗原（ハプテン、BSA/OVA結合体）
診断用抗体（anti-25-ヒドロキシビタミンD, anti-25-OH-(VD3+VD2)）および診断用ハプテン-キャリア結合体（BSA-25-ヒドロキシビタミンD, OVA-25-ヒドロキシビタミンD, KLH-25-ヒドロキシビタミンD）抗原は、代謝性疾患の25-OH-(VD3+VD2)検出のために、ELISAテスト、競争ELISA、ラテラルフローイムノアッセイ（LFIA）、化学発光イムノアッセイ（CLIA）、比濁法阻害イムノアッセイ（TINIA）およびPOCTで使用されます。
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製品情報
| Catalog No. | Description | US $ Price (per mg) |
|---|---|---|
| GMP-SMT-25-OH-(VD3+VD2)-Ag01 | BSA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) | $756.00 |
| GMP-SMT-25-OH-(VD3+VD2)-Ag02 | OVA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) | $756.00 |
| GMP-SMT-25-OH-(VD3+VD2)-Ab01 | Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb) | $1953.00 |
| GMP-SMT-25-OH-(VD3+VD2)-Ab02 | Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb) | $1953.00 |
Size： 1mg | 10mg | 100mg
製品説明
BSA-25 hydroxyvitamin D (25-OH-(VD3+VD2))
| Cat No. | GMP-SMT-25-OH-(VD3+VD2)-Ag01 |
| Product Name | BSA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) |
| Target | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) |
| Expression platform | Synthetic |
| Bioactivity validation | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in 25-OH-(VD3+VD2) level test of Metabolic diseases (bone fracture, coronary heart disease, cancer, and all-cause mortality) and related syndrome evaluation |
| Products description | Competitive immunoassay-validated hapten-carrier conjugates BSA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) / OVA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) is Synthetic. |
| Purity | High (TBD) |
| Application | Competitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
OVA-25 hydroxyvitamin D (25-OH-(VD3+VD2))
| Cat No. | GMP-SMT-25-OH-(VD3+VD2)-Ag02 |
| Product Name | OVA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) |
| Target | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) |
| Expression platform | Synthetic |
| Bioactivity validation | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in 25-OH-(VD3+VD2) level test of Metabolic diseases (bone fracture, coronary heart disease, cancer, and all-cause mortality) and related syndrome evaluation/td> |
| Products description | Competitive immunoassay-validated hapten-carrier conjugates BSA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) / OVA-25 hydroxyvitamin D (25-OH-(VD3+VD2)) is Synthetic. |
| Purity | High (TBD) |
| Application | Competitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb)
| Cat No. | GMP-SMT-25-OH-(VD3+VD2)-Ab01 |
| Product Name | Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb) |
| Target | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) |
| Expression platform | CHO |
| Isotypes | Rabbit IgG |
| Bioactivity validation | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other 25 hydroxyvitamin D (25-OH-(VD3+VD2)) antibodies in 25-OH-(VD3+VD2) level test of Metabolic diseases (bone fracture, coronary heart disease, cancer, and all-cause mortality) and related syndrome evaluation. |
| Tag | rabbit Fc |
| Products description | Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb) is a rabbit monoclonal antibody produced by CHO technology. |
| Purity | High (TBD) |
| Application | Sandwich ELISA, ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb)
| Cat No. | GMP-SMT-25-OH-(VD3+VD2)-Ab02 |
| Product Name | Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb) |
| Target | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) |
| Expression platform | CHO |
| Isotypes | Rabbit IgG1 |
| Bioactivity validation | 25 hydroxyvitamin D (25-OH-(VD3+VD2)) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other 25 hydroxyvitamin D (25-OH-(VD3+VD2)) antibodies in 25-OH-(VD3+VD2) level test of Metabolic diseases (bone fracture, coronary heart disease, cancer, and all-cause mortality) and related syndrome evaluation. |
| Tag | rabbit Fc |
| Products description | Anti-human 25 hydroxyvitamin D (25-OH-(VD3+VD2)) rabbit monoclonal antibody (rab mAb) is a rabbit monoclonal antibody produced by CHO. |
| Purity | Purity: ≥95% （SDS-PAGE） |
| Application | Sandwich ELISA, ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry. |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
参考文献
Validation Data
- FIG.1: Total 25-OH-VD identification ability
- FIG.2: Sample coincidence rate
- FIG.3: Standard curve
- FIG.4: Clinical comparative analysis
Figure 1. Total 25-OH-VD recognition ability; As can be seen from the figure above, 25-OH-VD2 and 25-OH-VD3 exhibit good cross-reactivity.
Genemedi's 25-OH-VD sandwich antibodies (GMP-SMT-25-OH-(VD3+VD2)-Ab01 and GMP-SMT-25-OH-(VD3+VD2)-Ab02) were validated on the direct chemiluminescence platform. The total amount of 25-OH-VD in the sample may be successfully detected thanks to the good cross-reactivity of 25-OH-VD2 and 25-OH-VD3.
Figure 2. Self-assessment clinical comparative analysis and Clinical comparative analysis of customer testing. The antibodies showed excellent agreement compared to mass spectrometry detection results, with an R2 as high as 0.9737 and a customer-validated R2 of 0.9538. The sandwich approach greatly improves the accuracy of immunoassays.
The VD sandwich antibody(GMP-SMT-25-OH-(VD3+VD2)-Ab01 and GMP-SMT-25-OH-(VD3+VD2)-Ab02) made by Genemedi was validated using a direct chemiluminescence platform with the industry's gold standard LC-MS/MS as a control to increase the accuracy of the 25-OH-VD immunoassay. When compared to the mass spectrometry detection results, these antibodies exhibited excellent consistency, with an R2 of up to 0.9737 and a customer-verified R2 of 0.9538. The sandwich approach greatly improved immunodetection accuracy.
Figure 3. Standard curve. As can be
seen from the figure above, Genemedi's 25-OH-VD sandwich antibody has a
detection concentration range of 0.1 to 80ng/mL.
The detection concentration range for
Genemedi's 25-OH-VD sandwich antibodies (GMP-SMT-25-OH-(VD3+VD2)-Ab01 and
GMP-SMT-25-OH-(VD3+VD2)-Ab02) is 0.1 to 80ng/mL.
Figure 4. Clinical comparative
analysis.(GMP-SMT-25-OH-(VD3+VD2)-Ab01 and GMP-SMT-25-OH-(VD3+VD2)-Ab02)
As can be seen from the figure above,
Detection employing 25-OH-VD sandwich antibodies validated by an enzymatic
chemiluminescence platform using an R2 of 0.9760, the data demonstrated strong
consistency using mass spectrometry (LC-MS/MS).
Click to get more Data / Case study about the product.
Target/Biomarker 情報
Vitamin D is a nutrient that is essential for healthy bones and teeth. There are two forms of vitamin D that are important for nutrition: vitamin D2 and vitamin D3. Vitamin D2 mainly comes from fortified foods like breakfast cereals, milk, and other dairy items. Vitamin D3 is made by your own body when you are exposed to sunlight. It is also found in some foods, including eggs and fatty fish, such as salmon, tuna, and mackerel. In your bloodstream, vitamin D2 and vitamin D3 are changed into a form of vitamin D called 25 hydroxyvitamin D, also known as 25(OH)D. A vitamin D blood test measures the level of 25(OH)D in your blood. Abnormal levels of vitamin D can indicate bone disorders, nutrition problems, organ damage, or other medical conditions. A vitamin D test is used to screen for or monitor bone disorders. It is also sometimes used to check vitamin D levels in people with chronic illnesses such as asthma, psoriasis, and certain autoimmune diseases.
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